Quantitative proteomic analysis of cerebrospinal fluid from patients with idiopathic facial nerve palsyArticle Published on 2023-04-012023-06-02 Journal: European journal of neurology [Category] 두창, 수두, 홍역, [키워드] cerebrospinal fluid chemokine facial palsy proteomics. [DOI] 10.1111/ene.15663 PMC 바로가기
Quantitative proteomic analysis of cerebrospinal fluid from patients with idiopathic facial nerve palsyArticle Published on 2023-04-012023-06-02 Journal: European journal of neurology [Category] 두창, 홍역, [키워드] cerebrospinal fluid chemokine facial palsy proteomics. [DOI] 10.1111/ene.15663 PMC 바로가기
High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19Clinical Trial Published on 2022-12-132023-07-10 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), [키워드] chemokine Predictive markers Respiratory distress syndrome SARS-CoV-2 Viral infection. [DOI] 10.1093/infdis/jiac313 PMC 바로가기 [Article Type] Clinical Trial
Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic reviewArticle Published on 2022-11-012022-11-16 Journal: Annals of Clinical and Translational Neurology [Category] 변종, [키워드] ACE affected Analysis association chemokine cohort study components conditions COVID-19 cytokine signaling Enzymes evolutionary relationship expression fatigue functional annotation Genetic genetic component Genetic variant highlight HLA-A HLA-C HLA-DQA1 HLA-DRB1 immune dysfunction Inflammation investigated Mental Ontology Pathogenesis Pathway analysis Pathways performed physical Protein Proteins receptor signaling significantly similarity Symptoms syndrome systematic review T cell activation TYK2 [DOI] 10.1002/acn3.51631 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
Transcriptional regulation and small compound targeting of ACE2 in lung epithelial cellsArticle Published on 2022-11-012022-11-15 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 진단, [키워드] 16HBE 16HBE cell 16HBE cells 6-O-angeloylplenolin ACE2 ACE2 expression addition administration Cell Centipeda Centipeda minima chemokine Chinese Compound conducted COVID-19 CX3CL1 CXCL13 dataset demonstrated downregulated entry of SARS-CoV-2 enzyme evaluated expression gene encoding HLF IL-6 inhibited inhibitor Interaction lung epithelial cell Lung epithelial cells lung tissue lung tissues mice modulate parental pathogen phosphorylated positively correlated promoter PROTECT Protein pseudovirus receptor reduced regulate Regulation S protein SARS-CoV-2 SARS-COV-2 infection screened STAT3 STAT3. stimulated suppressed target cells tested TFS Transcription transcription factor transfected with [DOI] 10.1038/s41401-022-00906-6 PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils. no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Describing immune factors associated with Hepatitis B surface antigen loss: A nested case-control study of a Chinese sample from Wuwei CityArticle Published on 2022-10-112023-06-13 Journal: Frontiers in Immunology [Category] B형 간염, Fulltext, [키워드] chemokine HBsAg interferon. MMP-1 TNF-R1 [DOI] 10.3389/fimmu.2022.1025654 PMC 바로가기